HPLC Method for Ethylenethiourea in Biological and Environmental Samples

Validated HPLC Method for Cynarin Determination in Biological Samples

A simple and sensitive method for the determination of cynarin is described and partially validated. The assay was used to determine the pharmacokinetic profile of cynarin after Wistar rat intravenous administration. Cynarin was isolated from rat plasma by solid-phase extraction. Separations were performed by reversed-phase high-performance liquid chromatography with ultraviolet detection. RESU...

hydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction

hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...

RP-HPLC Method for Simultaneous Estimation of Vigabatrin, GABA and Taurine in Biological Samples

HPLC assay for determination of amphotericin B in biological samples.

A fast and selective HPLC method for assaying amphotericin B in biological samples was developed and validated. The chromatographic separation was achieved in less than 12 min on a reverse-phase C(18) column using an acetonitrile-acetic acid-water (52:4.3:43.7, v/v/v) mixture as mobile phase. The flow rate was 1 mL/min and the effluent was monitored at 406 nm. A linear response over the concent...

Rapid HPLC Method for Monitoring Relevant Residues of Pharmaceuticals Products in Environmental Samples

This work presents a multi-residue analytical method based on solid phase extraction (SPE) followed by high-performance liquid chromatographic (HPLC) with diode array (DAD) detection for the simultaneous determination of a group of pharmaceutical products that include ten antidepressants and three anticancerigenic in environmental samples (water and soil). Baseline separation of the studied com...